Collaborative Interdisciplinary Team Science Awards will foster the application of interdisciplinary, integrative and/or paradigm-shifting approaches to address complex challenges in biomedical research relevant to the National Institute of Diabetes and Digestive and Kidney Diseases. The NIDDK supported R24 grant mechanism is designed to apply the flexibility of the Research Resource Project Grant mechanism (R24) to accommodate many forms of approaches including discovery-based or resource-generating and hypothesis-driven or hypothesis-generating science. Information regarding the mission of NIDDK and its constituent Extramural Scientific Divisions, including Diabetes, Endocrinology and Metabolic Diseases (DEM), Digestive Diseases and Nutrition (DDN), and Kidney, Urology and Hematologic Diseases (KUH) may be found at: https://www.niddk.nih.gov/research-funding/research-programs.